Development and characterization of a camelid single Domain antibody– Urease conjugate That Targets Vascular endothelial growth Factor receptor 2


Angiogenesis is the process of new blood vessel formation and is essential for a tumor to
grow beyond a certain size. Tumors secrete the pro-angiogenic factor vascular endothelial
growth factor, which acts upon local endothelial cells by binding to vascular endothelial
growth factor receptors (VEGFRs). In this study, we describe the development and
characterization of V21-DOS47, an immunoconjugate that targets VEGFR2. V21-DOS47
is composed of a camelid single domain anti-VEGFR2 antibody (V21) and the enzyme



tian 2017 Development and Characterisation of a Camelid single domain ab urease conjugate that targets vegfr2